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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1
All Species:
44.85
Human Site:
Y537
Identified Species:
75.9
UniProt:
P11387
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11387
NP_003277.1
765
90726
Y537
L
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
T405
D
N
L
F
D
R
L
T
T
T
S
L
N
K
H
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
Y539
L
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
Dog
Lupus familis
XP_534420
1004
115318
Y776
L
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
Cat
Felis silvestris
Mouse
Mus musculus
Q04750
767
90857
Y539
P
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
Rat
Rattus norvegicus
Q9WUL0
767
90741
Y539
P
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509816
781
92543
Y553
L
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
Chicken
Gallus gallus
Frog
Xenopus laevis
P41512
829
98212
Y593
P
G
K
D
S
I
R
Y
Y
N
K
V
P
V
E
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
Y759
P
G
K
D
S
I
R
Y
Y
N
E
V
E
V
E
Honey Bee
Apis mellifera
XP_396203
973
114099
Y762
L
G
K
D
S
I
R
Y
Y
N
E
V
P
V
E
Nematode Worm
Caenorhab. elegans
O17966
806
94011
Y586
L
G
K
D
S
I
R
Y
F
N
R
V
S
V
E
Sea Urchin
Strong. purpuratus
XP_793285
879
100968
Y651
L
G
K
D
S
I
R
Y
E
N
S
V
P
V
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
Y694
V
E
V
E
P
L
V
Y
K
A
I
G
Q
F
Q
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
F474
V
E
V
D
K
Q
V
F
K
N
L
T
I
F
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54.1
99
74.8
N.A.
97
97
N.A.
90.4
N.A.
75
N.A.
N.A.
49.6
53.5
54.8
45.3
Protein Similarity:
100
67.4
99.6
75.8
N.A.
98.6
98.6
N.A.
93.8
N.A.
82.7
N.A.
N.A.
62.3
64.4
69.1
58
P-Site Identity:
100
0
100
100
N.A.
93.3
93.3
N.A.
100
N.A.
93.3
N.A.
N.A.
80
93.3
80
86.6
P-Site Similarity:
100
6.6
100
100
N.A.
93.3
93.3
N.A.
100
N.A.
93.3
N.A.
N.A.
86.6
100
93.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
46.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
63.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
86
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
15
0
8
0
0
0
0
8
0
15
0
8
0
79
% E
% Phe:
0
0
0
8
0
0
0
8
8
0
0
0
0
15
0
% F
% Gly:
0
79
0
0
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
79
0
0
0
0
8
0
8
0
0
% I
% Lys:
0
0
79
0
8
0
0
0
15
0
50
0
0
8
8
% K
% Leu:
50
0
8
0
0
8
8
0
0
0
8
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
86
0
0
8
0
0
% N
% Pro:
29
0
0
0
8
0
0
0
0
0
0
0
65
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
8
% Q
% Arg:
0
0
0
0
0
8
79
0
0
0
8
0
0
0
0
% R
% Ser:
0
0
0
0
79
0
0
0
0
0
15
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
8
8
8
0
8
0
0
0
% T
% Val:
15
0
15
0
0
0
15
0
0
0
0
79
0
79
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
86
65
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _